Rotigotine transdermal patches (Neupro) for the treatment of Parkinson's disease.
نویسنده
چکیده
The main clinical features of Parkinson’s disease are tremor, muscular rigidity, akinesia (inability to move), and postural instability. Other features of the disease include changes in gait, mask-like face, micrographia (progressively smaller handwriting), and psychiatric symptoms; depression occurs in 50% of patients over the course of their illness. The diagnosis is made by clinical symptoms and the patient’s response to antiparkinsonian drug treatment.
منابع مشابه
Rotigotine transdermal system: a short review
Rotigotine (Neupro((R))) is a new non-ergolinic dopamine agonist transdermal patch that can be applied once daily. To date, it is approved for the treatment of early Parkinson's disease as monotherapy and has been shown to be effective in the treatment of advanced-stage Parkinson's disease and restless legs syndrome in several clinical trials. This review gives an overview of physical, chemical...
متن کاملNight-time use of rotigotine in advanced Parkinson's disease.
Transdermal rotigotine was used in six patients with advanced Parkinson's disease and sleep disorders (UPDRS part II item 12 score ≥ 2) receiving oral levodopa and diurnal apomorphine infusions. Transdermal rotigotine (2-4 mg/24h) was used at night for four months. Sleep disorders improved, the total Parkinson's Disease Sleep Scale score falling by an average of 45%; significant improvements em...
متن کاملRotigotine Transdermal Patch for the Treatment of Restless Legs Syndrome
Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson’s disease or with moderate-to-severe restless legs syndrome (RLS). This review comprises an overview of the pharmacokinetics, the pharmacodynamics and...
متن کاملTransdermal rotigotine: double-blind, placebo-controlled trial in Parkinson disease.
OBJECTIVE To assess the response to the rotigotine transdermal system (Neupro; Schwarz Pharma Ltd, Monheim, Germany), a nonergolinic dopamine agonist, in patients with early Parkinson disease. DESIGN Randomized, double-blind, multicenter, placebo-controlled study. SETTING Fifty sites in the United States and Canada. PATIENTS Two hundred seventy-seven patients with early Parkinson disease....
متن کاملEvaluation of rotigotine transdermal patch for the treatment of apathy and motor symptoms in Parkinson’s disease
BACKGROUND This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson's disease (PD). METHODS Patients with PD-associated apathy (Unified Parkinson's Disease Rating Scale [UPDRS] I item 4 [motivation] ≥2 and patient-rated Apathy Scale [AS] ≥14) were randomized 1:1:1 to "low-dose" rotigo...
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ورودعنوان ژورنال:
- Issues in emerging health technologies
دوره 112 شماره
صفحات -
تاریخ انتشار 2008